Will it be another hit for the pair?
The track, which premiered on radio today, features Florence's dulcet vocals backed by Calvin's trademark dance beats and it's got our feet tapping in the office after the long bank holiday weekend.
Sweet Nothing will feature on Calvin's upcoming third album, 18 Months, and Florence isn't the only esteemed vocalist he's enlisted help from for the LP. He's collaborated with Tinie Tempah, Kelis, Ne-Yo, Example, Ellie Goulding and of course Rihanna on their worldwide hit We Found Love.
Will Sweet Nothing be another chart-topper for the duo? Have a listen below and let us know what you think.
Oh and by the way, Happy Birthday to Florence - it's her birthday today!